VDAC regulation by the Bcl-2 family of proteins
نویسندگان
چکیده
منابع مشابه
Regulation of ceramide channels by Bcl-2 family proteins.
Mitochondrial outer membrane permeabilization to proteins, an irreversible step in apoptosis by which critical proteins are released, is tightly regulated by Bcl-2 family proteins. The exact nature of the release pathway is still undefined. Ceramide is an important sphingolipid, involved in various cellular processes including apoptosis. Here we describe the structural properties of ceramide ch...
متن کاملThe bcl-2 family of proteins.
The bcl-2 family of proteins play an important role in the control of apoptosis. Family members exist which are either pro- or anti-apoptotic and their activity appears to control a checkpoint between signals from the cell surface and activation of the ICE-family of proteases. Despite having a key role to play in apoptosis, the mechanism of action of these proteins can only, at present, be infe...
متن کاملRegulation of mitochondrial membrane permeabilization by BCL-2 family proteins and caspases.
Mitochondria play an important role in the integration and transmission of cell death signals, activating caspases and other cell death execution events by releasing apoptogenic proteins from the intermembrane space. The BCL-2 family of proteins localize (or can be targeted) to mitochondria and regulate the permeability of the mitochondrial outer membrane to these apoptotic factors. Recent evid...
متن کاملThe effect of carvacrol on transcription levels of Bcl-2 family proteins in hypertrophied heart of rats
Introduction: Cardiomyocytes apoptosis contributes to the development of left ventricular hypertrophy. The Bcl-2 family members are important regulators of mitochondrial pathway of apoptosis. Monoterpenoid phenol –carvacrol– possesses strong antioxidant properties. The present study aimed to evaluate the effect of carvacrol on transcription level of pro-apoptotic (Bad and Bax) and...
متن کامل[The role of bcl-2 family proteins in psoriasis].
Apoptosis is a physiological process of programmed cell death responsible for homeostasis in the body. In skin, apoptotic process regulates keratinocyte proliferation and differentiation in that way maintaining homeostasis of epidermal compartment. The process of apoptosis is controlled by proteins of the Bcl-2 family, several proapoptotic (Bax, Bak, Bad) and antiapoptotic (Bcl-2, Bcl-x(L)) pro...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2000
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4400780